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Anti-Fbxo43 [2EMI-2A10]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  EMI-2 (Endogenous Meiotic inhibitor 2)
Reactivity Mouse
Relevance The monoclonal anti-EMI-2 antibody, clone 2EMI-2A10, has been validated for ELISA, Western Blot and Immunocytochemistry. The Endogenous meiotic inhibitor 2 is also known as F-box only protein 43 (Fbxo43). It is required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. It appears to act by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. EMI-2 probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Host Mouse
Immunogen CRRGSAKARGSKDVL (synthetic peptide corresponding to aa 613 to 627 of mouse EMI-2)
Subclass IgA kappa
Notes Available in 100ul unit as ascites.

Recommended dilutions: 1/500-1/5000
Research Area Epigenetics & Nuclear Signalling, Protein Degradation

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