Anti-LewisX [29]
Invented by Prof Nancy Hogg from Cancer Research UK London Research Institute: Lincoln's Inn Fields
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 151042 |
| Applications | FACS |
| Antigen/Gene or Protein Targets | Lewis X (CD15) |
| Synonyms | Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; ELAM-1 Ligand Fucosyltransferase; FUC-TIV; FCT3A; ELFT; Stage-Specific Embryonic Antigen; Alpha (1,3) Fucosyltransferase; EC 2.4.1.65; Lewis X; SSEA-1; FUTIV; CD15; LeX |
| Reactivity | Human |
| Relevance |
Monoclonal antibody directed at against Lewis X antigen, with use in differentiating between leukaemia’s and aids in the purification of stem cells. Background and Research Application Lewis X (CD15) is a branched pentasaccharide found on glycolipids, glycoproteins and proteoglycans of cells of gastric mucosa, nervous system, neutrophils, eosinophils, and monocytes. Lewis X is distributed abnormally in myeloid leukaemia’s and is commonly used in the diagnosis of Hodgkin’s disease. Lewis X is believed to enhance cell adhesion, either directly or by promoting integrin activation. Cells with high surface expression of Lewis X antigen, display strong self-aggregation, based on calcium-dependent Lewis X-Lewis X interaction. Anti-Lewis X (29) is useful for leukaemia typing and the purification of stem cells. |
| Host | Mouse |
| Immunogen | Fibronectin purified human monocytes . |
| Immunogen UniProt ID | P22083 |
| Subclass | IgM |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Cancer, Immunology |
References: 1 entry
Bernstein I & Self S. Report of the myeloid section of the Second International Workshop on Leucocyte Typing II, Human leucocyte Differentiation Antigens. Published by Springer-Verlag, New York. 1986.
Add a reference
References: 1 entry
Bernstein I & Self S. Report of the myeloid section of the Second International Workshop on Leucocyte Typing II, Human leucocyte Differentiation Antigens. Published by Springer-Verlag, New York. 1986.
Add a reference
