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Catalogue Number 151036
Applications FACS IHC IP Fn
Antigen/Gene or Protein Targets ICAM1 (CD54)
Synonyms Intercellular Adhesion Molecule 1; Major Group Rhinovirus Receptor; ICAM-1; Cell Surface Glycoprotein P3.58; Human Rhinovirus Receptor; P3.58; CD54; BB2
Reactivity Human
Relevance ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18).
Host Mouse
Immunogen Rheumatoid synovial cells and human monocytes.
Subclass IgG1
Positive Control Tonsil
Molecular Weight (kDa) 85-115
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions E4 +10% FCS
Strain Balb/c
Research Area Adhesion, Cardiovascular, Immunology, Stem Cell Biology

References: 14 entries

Vásquez et al. 2016. Microbes Infect. :. PMID: 27717894.

Plasmodium falciparum isolates from patients with uncomplicated malaria promote endothelial inflammation.

Europe PMC ID: 27717894

Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.

Europe PMC ID: 26857242

Novotny et al. 2016. Cell Microbiol. :. PMID: 26857242.

Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.

Europe PMC ID: 20977750

El-Bikai et al. 2010. Arthritis Res Ther. 12(5):R201. PMID: 20977750.

Conway et al. 2010. Am J Physiol Heart Circ Physiol. 298(2):H367-74. PMID: 19915176.

Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal.

Europe PMC ID: 19915176

Lauriello et al. 2005. Acta Otorhinolaryngol Ital. 25(5):284-91. PMID: 16602327.

A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis.

Europe PMC ID: 16602327

Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.

The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.

Europe PMC ID: 10998349

Dransfield et al. 1992. J Cell Biol. 116(6):1527-35. PMID: 1541641.

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.

Europe PMC ID: 1541641


Add a reference

References: 14 entries

Vásquez et al. 2016. Microbes Infect. :. PMID: 27717894.

Plasmodium falciparum isolates from patients with uncomplicated malaria promote endothelial inflammation.

Europe PMC ID: 27717894

Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.

Europe PMC ID: 26857242

Novotny et al. 2016. Cell Microbiol. :. PMID: 26857242.

Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.

Europe PMC ID: 20977750

El-Bikai et al. 2010. Arthritis Res Ther. 12(5):R201. PMID: 20977750.

Conway et al. 2010. Am J Physiol Heart Circ Physiol. 298(2):H367-74. PMID: 19915176.

Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal.

Europe PMC ID: 19915176

Lauriello et al. 2005. Acta Otorhinolaryngol Ital. 25(5):284-91. PMID: 16602327.

A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis.

Europe PMC ID: 16602327

Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.

The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.

Europe PMC ID: 10998349

Dransfield et al. 1992. J Cell Biol. 116(6):1527-35. PMID: 1541641.

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.

Europe PMC ID: 1541641


Add a reference

References: 14 entries

Vásquez et al. 2016. Microbes Infect. :. PMID: 27717894.

Plasmodium falciparum isolates from patients with uncomplicated malaria promote endothelial inflammation.

Intercellular adhesion molecule 1 serves as a primary cognate receptor for the Type IV pilus of nontypeable Haemophilus influenzae.

Novotny et al. 2016. Cell Microbiol. :. PMID: 26857242.

Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.

El-Bikai et al. 2010. Arthritis Res Ther. 12(5):R201. PMID: 20977750.

Conway et al. 2010. Am J Physiol Heart Circ Physiol. 298(2):H367-74. PMID: 19915176.

Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal.

Lauriello et al. 2005. Acta Otorhinolaryngol Ital. 25(5):284-91. PMID: 16602327.

A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis.

Stanley et al. 2000. Biochem J. 351(Pt 1):79-86. PMID: 10998349.

The second domain of intercellular adhesion molecule-1 (ICAM-1) maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first domain.

Dransfield et al. 1992. J Cell Biol. 116(6):1527-35. PMID: 1541641.

Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.


Add a reference


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