Anti-Rb1 [Rb1 (1F8)]
Invented by David Lane from Karolinska Institutet
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (12)
- Inventor Info
Info
| Catalogue Number | 151156 |
| Applications | IHC IF IP |
| Antigen/Gene or Protein Targets | Retinoblastoma (Rb1) |
| Reactivity | Human |
| Relevance | The Retinoblastoma protein (Rb) is a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma. |
| Host | Mouse |
| Immunogen | Rb-b-galactosidase fusion protein spanning nucleotides 1126-1973 and representing 283 mino acids of Human Rb cDNA |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 105 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 10% FCS. |
| Strain | Balb/c |
| Notes | Rb1 may be used in sensitive assays for Rb complexed to the T antigen |
| Research Area | Cancer, Cell Cycle, Cell Type or Organelle Marker |
References: 12 entries
Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.
Europe PMC ID: 25487143
Ragazzon et al. 2014. Eur J Endocrinol. 2014 Feb 4;170(3):385-91. PMID: 24347427
IHC
Bandyopadhyay et al. 2007. Aging Cell. 6(4):577-91. PMID: 17578512.
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.
Europe PMC ID: 17578512
Lee et al. 2007. Clin Cancer Res. 13(3):832-8. PMID: 17289874.
Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer.
Europe PMC ID: 17289874
Bartkova et al. 2003. J Pathol. 200(2):149-56. PMID: 12754735.
Deregulation of the RB pathway in human testicular germ cell tumours.
Europe PMC ID: 12754735
Bártek et al. 1992. Oncogene. 7(1):101-8. PMID: 1741157.
Cellular localization and T antigen binding of the retinoblastoma protein.
Europe PMC ID: 1741157
Grand et al. 1989. Oncogene. 4(11):1291-8. PMID: 2682458.
The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.
Europe PMC ID: 2682458
Add a reference
References: 12 entries
Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.
Ragazzon et al. 2014. Eur J Endocrinol. 2014 Feb 4;170(3):385-91. PMID: 24347427
IHC
Bandyopadhyay et al. 2007. Aging Cell. 6(4):577-91. PMID: 17578512.
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.
Lee et al. 2007. Clin Cancer Res. 13(3):832-8. PMID: 17289874.
Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer.
Bartkova et al. 2003. J Pathol. 200(2):149-56. PMID: 12754735.
Deregulation of the RB pathway in human testicular germ cell tumours.
Bártek et al. 1992. Oncogene. 7(1):101-8. PMID: 1741157.
Cellular localization and T antigen binding of the retinoblastoma protein.
Grand et al. 1989. Oncogene. 4(11):1291-8. PMID: 2682458.
The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.
Add a reference
