Log in Register
Menu

Anti-Rb1 [Rb1 (1F8)]

Invented by David Lane at Karolinska Institutet

Info

Catalogue Number 151156
Applications IHC IF IP
Antigen/Gene or Protein Targets Retinoblastoma (Rb1)
Reactivity Human
Relevance The Retinoblastoma protein (Rb) is a transcription factor that controls cell cycle progression (at the G1/S phase transition) through its repression of E2F-mediated transcription. Mutation of the Rb gene is found frequently in human sarcomas, lung, bladder and breast carcinomas and is the molecular basis for hereditary disposition to retinoblastoma.
Host Mouse
Immunogen Rb-b-galactosidase fusion protein spanning nucleotides 1126-1973 and representing 283 mino acids of Human Rb cDNA
Subclass IgG1
Molecular Weight (kDa) 105
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 10% FCS.
Strain Balb/c
Notes Rb1 may be used in sensitive assays for Rb complexed to the T antigen
Research Area Cancer, Cell Cycle, Cell Type or Organelle Marker

References: 12 entries

Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.

Europe PMC ID: 25487143

Ragazzon et al. 2014. Eur J Endocrinol. 2014 Feb 4;170(3):385-91. PMID: 24347427

IHC

Bandyopadhyay et al. 2007. Aging Cell. 6(4):577-91. PMID: 17578512.

Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.

Europe PMC ID: 17578512

Lee et al. 2007. Clin Cancer Res. 13(3):832-8. PMID: 17289874.

Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer.

Europe PMC ID: 17289874

Bartkova et al. 2003. J Pathol. 200(2):149-56. PMID: 12754735.

Deregulation of the RB pathway in human testicular germ cell tumours.

Europe PMC ID: 12754735

Bártek et al. 1992. Oncogene. 7(1):101-8. PMID: 1741157.

Cellular localization and T antigen binding of the retinoblastoma protein.

Europe PMC ID: 1741157

Grand et al. 1989. Oncogene. 4(11):1291-8. PMID: 2682458.

The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.

Europe PMC ID: 2682458


Add a reference

References: 12 entries

Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.

Europe PMC ID: 25487143

Ragazzon et al. 2014. Eur J Endocrinol. 2014 Feb 4;170(3):385-91. PMID: 24347427

IHC

Bandyopadhyay et al. 2007. Aging Cell. 6(4):577-91. PMID: 17578512.

Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.

Europe PMC ID: 17578512

Lee et al. 2007. Clin Cancer Res. 13(3):832-8. PMID: 17289874.

Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer.

Europe PMC ID: 17289874

Bartkova et al. 2003. J Pathol. 200(2):149-56. PMID: 12754735.

Deregulation of the RB pathway in human testicular germ cell tumours.

Europe PMC ID: 12754735

Bártek et al. 1992. Oncogene. 7(1):101-8. PMID: 1741157.

Cellular localization and T antigen binding of the retinoblastoma protein.

Europe PMC ID: 1741157

Grand et al. 1989. Oncogene. 4(11):1291-8. PMID: 2682458.

The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.

Europe PMC ID: 2682458


Add a reference

References: 12 entries

Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.

Ragazzon et al. 2014. Eur J Endocrinol. 2014 Feb 4;170(3):385-91. PMID: 24347427

IHC

Bandyopadhyay et al. 2007. Aging Cell. 6(4):577-91. PMID: 17578512.

Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi.

Lee et al. 2007. Clin Cancer Res. 13(3):832-8. PMID: 17289874.

Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer.

Bartkova et al. 2003. J Pathol. 200(2):149-56. PMID: 12754735.

Deregulation of the RB pathway in human testicular germ cell tumours.

Bártek et al. 1992. Oncogene. 7(1):101-8. PMID: 1741157.

Cellular localization and T antigen binding of the retinoblastoma protein.

Grand et al. 1989. Oncogene. 4(11):1291-8. PMID: 2682458.

The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.


Add a reference


This reagent does not have any reviews at the moment.