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Anti-UL48 [5GV-2]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  VP16 
Reactivity Virus
Relevance UL48 (Herpes virus VP16) activates expression of immediate early (IE) genes in virally-infected cells. It acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection. UL48 may play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis.
Host Mouse
Immunogen (C)DFDLDMLGDGDS
Subclass IgG1 kappa
Notes Available in 100ul unit
Research Area Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Gene Expression, Virology

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