Anti-ErbB3 [SGP1]
Invented at
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- References (5)
- Inventor Info
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| Catalogue Number | 151159 |
| Applications | FACS IHC IF IP |
| Antigen/Gene or Protein Targets | ErbB3 (Her3) |
| Reactivity | Human |
| Relevance | The EGFR family of type I growth factor receptor tyrosine kinases includes EGFR (HER1), c-erbB2 (HER2; neu), c-erbB3 (HER3) and c-erbB4 (HER4). c-erbB3 is normally found in non-dividing differentiated epithelial cells, neurones and hepatocytes. It has approximately 80% prevalence in a wide variety of tumours of the gastro-intestinal tract, and approximately 20% prevalence in breast cancer. |
| Host | Mouse |
| Immunogen | c-erb B3 protein from transfected human kidney fibroblasts purified by wheatgerm lectin affinity chromatography |
| Subclass | IgG1 kappa |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction |
References: 5 entries
Vollmann-Zwerenz et al. 2010. Cytometry A. 77(4):387-98. PMID: 20151455.
FACS
Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry--possibilities and limitations.
Europe PMC ID: 20151455
Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.
Europe PMC ID: 9771476
Rajkumar et al. 1994. Br J Cancer. 70(3):459-65. PMID: 8080731.
IP
A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines.
Europe PMC ID: 8080731
Add a reference
References: 5 entries
Vollmann-Zwerenz et al. 2010. Cytometry A. 77(4):387-98. PMID: 20151455.
FACS
Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry--possibilities and limitations.
Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types.
Rajkumar et al. 1994. Br J Cancer. 70(3):459-65. PMID: 8080731.
IP
A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines.
Add a reference