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Anti-PCNA [PC10]


Catalogue Number 151148
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein
Synonyms Proliferating Cell Nuclear Antigen; DNA Polymerase Delta Auxiliary Protein; ATLD2
Reactivity Human, Insect and Schizosaccharomyces pombe
Relevance PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is potentially a therapeutic target in cancer therapy and a useful marker for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). This antibody can be used for grading of different neoplasms, e.g. astrocytoma. It can be of diagnostic and prognostic value.
Host Mouse
Immunogen Protein A-PCNA fusion obtained from pC2T.
Subclass IgG2a
Molecular Weight (kDa) 36
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Notes Recommended for use on formalin-fixed paraffin embedded sections. NEUTRAL ELUTE ONLY.
Research Area Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling

References: 8 entries

Pacaud et al. 2014. Sci Rep. 4:4230. PMID: 24637615.

Kuang et al. 2013. World J Gastroenterol. 19(39):6637-44. PMID: 24151393.

Cho et al. 2013. PLoS One. 8(10):e76860. PMID: 24146937.

Landberg et al. 1991. Cancer Res. 51(17):4570-4. PMID: 1678682.

Yu et al. 1991. Histopathology. 19(1):29-33. PMID: 1680785.

Woods et al. 1991. Histopathology. 19(1):21-7. PMID: 1680784.

Hall et al. 1990. J Pathol. 162(4):285-94. PMID: 1981239.

Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.

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