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|Applications||FACS IHC IF IP WB|
|Antigen/Gene or Protein Targets||Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein|
|Reactivity||Human, Insect and Saccharomyces|
|Relevance||PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is potentially a therapeutic target in cancer therapy and a useful marker for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). This antibody can be used for grading of different neoplasms, e.g. astrocytoma. It can be of diagnostic and prognostic value.|
|Immunogen||Protein A-PCNA fusion obtained from pC2T.|
|Molecular Weight (kDa)||36|
|Research Area||Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling|
Recommended for use on formalin-fixed paraffin embedded sections. NEUTRAL ELUTE ONLY.
Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.
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