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Anti-PCNA, Recombinant [PC10]

Invented by David Lane at Karolinska Institutet

Info

Catalogue Number 152584
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein
Reactivity Human, Insect and Saccharomyces
Relevance PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is potentially a therapeutic target in cancer therapy and a useful marker for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). This antibody can be used for grading of different neoplasms, e.g. astrocytoma. It can be of diagnostic and prognostic value.
Host Mouse
Immunogen Protein A-PCNA fusion obtained from pC2T.
Subclass IgG2a
Formulation PBS only
Concentration 1mg/ml
Molecular Weight (kDa) 36
Research Area Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling
Notes Recommended for use on formalin-fixed paraffin embedded sections. NEUTRAL ELUTE ONLY.

Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma.

References: 1 entry

Original hybridoma first published in Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.


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References: 1 entry

Original hybridoma first published in Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.


Add a reference

References: 1 entry

Original hybridoma first published in Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.


Add a reference


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