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Anti-PCNA [PC11]

Invented by David Lane at Karolinska Institutet

Info

Catalogue Number 151149
Applications IHC WB
Antigen/Gene or Protein Targets Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein.
Synonyms Proliferating Cell Nuclear Antigen; DNA Polymerase Delta Auxiliary Protein; ATLD2
Reactivity Human and Schizosaccharomyces pombe
Relevance PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis).
Host Mouse
Immunogen Protein A-PCNA fusion obtained from pC2T.
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Research Area Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling

References: 6 entries

Espinosa et al. 2013. PLoS One. 8(2):e55975. PMID: 23405241.

Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.

Europe PMC ID: 23405241

Singh et al. 2011. PLoS One. 6(9):e25125. PMID: 21966433.

Partial inhibition of estrogen-induced mammary carcinogenesis in rats by tamoxifen: balance between oxidant stress and estrogen responsiveness.

Europe PMC ID: 21966433

Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form.

Europe PMC ID: 1695635


Add a reference

References: 6 entries

Espinosa et al. 2013. PLoS One. 8(2):e55975. PMID: 23405241.

Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.

Europe PMC ID: 23405241

Singh et al. 2011. PLoS One. 6(9):e25125. PMID: 21966433.

Partial inhibition of estrogen-induced mammary carcinogenesis in rats by tamoxifen: balance between oxidant stress and estrogen responsiveness.

Europe PMC ID: 21966433

Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form.

Europe PMC ID: 1695635


Add a reference

References: 6 entries

Espinosa et al. 2013. PLoS One. 8(2):e55975. PMID: 23405241.

Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.

Singh et al. 2011. PLoS One. 6(9):e25125. PMID: 21966433.

Partial inhibition of estrogen-induced mammary carcinogenesis in rats by tamoxifen: balance between oxidant stress and estrogen responsiveness.

Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form.


Add a reference


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