Anti-PCNA [PC11]
Invented by David Lane from Karolinska Institutet
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
- Datasheet
- References (6)
- Inventor Info
Info
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| Catalogue Number | 151149 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | Proliferating cell nuclear antigen, (PCNA), also known as cyclin or polymerase delta accessory protein. |
| Synonyms | Proliferating Cell Nuclear Antigen; DNA Polymerase Delta Auxiliary Protein; ATLD2 |
| Reactivity | Human and Schizosaccharomyces pombe |
| Relevance | PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is a potentially useful marker of cells with proliferative potential and for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). |
| Host | Mouse |
| Immunogen | Protein A-PCNA fusion obtained from pC2T. |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Research Area | Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling |
References: 6 entries
Espinosa et al. 2013. PLoS One. 8(2):e55975. PMID: 23405241.
Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.
Europe PMC ID: 23405241
Singh et al. 2011. PLoS One. 6(9):e25125. PMID: 21966433.
Partial inhibition of estrogen-induced mammary carcinogenesis in rats by tamoxifen: balance between oxidant stress and estrogen responsiveness.
Europe PMC ID: 21966433
Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.
Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form.
Europe PMC ID: 1695635
Add a reference
References: 6 entries
Espinosa et al. 2013. PLoS One. 8(2):e55975. PMID: 23405241.
Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.
Singh et al. 2011. PLoS One. 6(9):e25125. PMID: 21966433.
Partial inhibition of estrogen-induced mammary carcinogenesis in rats by tamoxifen: balance between oxidant stress and estrogen responsiveness.
Waseem et al. 1990. J Cell Sci. 96 ( Pt 1):121-9. PMID: 1695635.
Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form.
Add a reference
