Anti-ESR2 [9ERß-1F5]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | Estrogen Receptor a & b (C region) |
| Reactivity | Human and Mouse |
| Relevance | The monoclonal anti‐Estrogen receptors a and b (C‐region), clone 9ERß‐1F5, recognises human and mouse estrogen receptors alpha and beta. It has been validated for ELISA, Western Blot (natural and recombinant proteins) and Immunofluorescence. Estrogen receptors are activated by the hormone estrogen (17β-estradiol). Once activated by estrogen, the ER is able to translocate into the nucleus and acts as a a DNA-binding transcription factor. ERa and ERb regulate gene transcription by direct binding to estrogen-regulated elements (ERE) or indirectly by protein-protein interaction with transcription factor activator protein-1 (AP-1) and Sp1. Estrogens are important for mammary gland morphogenesis and differentiation. |
| Host | Mouse |
| Immunogen | Recombinant human ERß full length protein, |
| Subclass | IgG2b kappa |
| Notes |
Available in 100ul unit as ascites. Recommended dilutions: 1/500‐1/5000 |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology |
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