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Anti-ESR2 [9ERß-1F5]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  Estrogen Receptor a & b (C region)
Reactivity Human and Mouse
Relevance The monoclonal anti‐Estrogen receptors a and b (C‐region), clone 9ERß‐1F5, recognises human and mouse estrogen receptors alpha and beta. It has been validated for ELISA, Western Blot (natural and recombinant proteins) and Immunofluorescence. Estrogen receptors are activated by the hormone estrogen (17β-estradiol). Once activated by estrogen, the ER is able to translocate into the nucleus and acts as a a DNA-binding transcription factor. ERa and ERb regulate gene transcription by direct binding to estrogen-regulated elements (ERE) or indirectly by protein-protein interaction with transcription factor activator protein-1 (AP-1) and Sp1. Estrogens are important for mammary gland morphogenesis and differentiation.
Host Mouse
Immunogen Recombinant human ERß full length protein,
Subclass IgG2b kappa
Notes Available in 100ul unit as ascites.

Recommended dilutions: 1/500‐1/5000
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology

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