Cancer Research Technology
Log in Register
Menu

anti-carbonic anhydrase IX (CA-IX) iBody small molecule (tool compound)
RECENTLY UPDATED

Invented by Jan Konvalinka , Jiří Schimer , Tomas Knedlik , Jan Tykvart , Frantisek Sedlak , Pavel Majer , Vaclav Navratil , Petr Cigler , Vladimir Subr , Karel Ulbich , Jiri Stroham , Pavel Sacha
Invented at Institute of Organic Chemistry and Biochemistry , Institute of Macromolecular Chemistry , Charles University

Info

Catalogue Number 157993
Antigen/Gene or Protein Targets Targeting human Carbonic Anhydrase (CAIX) using CAIX specific inhibitor
Synonyms Carbonic Anyhdrase IX; CA9; CA-IX
Relevance An enzyme that in humans is encoded by the CA9 gene.

- iBodies® are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation.
- These iBodies® consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores).
- These iBodies® have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays.
Research Area Cell Signaling & Signal Transduction, Other
Notes HPMA conjugate characteristics:
MW: 111 000g/mol
#Biotins/molecule: 33
Fluorochrome name: ATTO488
#Fluorochrome/molecule: 6

iBodies(R) is a registered trade mark of IOCB Tech s.r.o.

References

There are 3 reference entries for this reagent.

View All References

References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


Add a reference

References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


Add a reference

Inventor Information

Inventors

Jan Konvalinka

Jan Konvalinka

Jiří Schimer

Jiří Schimer

Tomas Knedlik

Tomas Knedlik

Jan Tykvart

Jan Tykvart

Frantisek Sedlak

Frantisek Sedlak

Pavel Majer

Pavel Majer

Vaclav Navratil

Vaclav Navratil

Petr Cigler

Petr Cigler

Vladimir Subr

Vladimir Subr

Karel Ulbich

Karel Ulbich

Jiri Stroham

Jiri Stroham

Pavel Sacha

Pavel Sacha

Add an inventor