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anti-fibroblast activation protein (FAP) iBody small molecule (tool compound)

Invented by Pavel Sacha, at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Jan Konvalinka , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Jiří Schimer , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Tomas Knedlik, at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Jan Tykvart , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Frantisek Sedlak , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Pavel Majer , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Vaclav Navratil , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Petr Cigler , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Vladimir Subr , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Karel Ulbich , at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry Jiri Stroham at Charles University, Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry

Info

Catalogue Number 157998
Synonyms Fibroblast Activation Protein; prolyl endopeptidase FAP
Relevance Targeting human Fibroblast Activation Protein (FAP) using FAP specific inhibitor.

- iBodies® are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation.
- These iBodies® consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores).
- These iBodies® have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays.
Key Attributes HPMA conjugate characteristics:
MW: 79 875g/mol
#Biotins/molecule: 8
Fluorochrome name: ATTO488
#Fluorochrome/molecule: 5

iBodies(R) is a registered trade mark of IOCB Tech s.r.o.
Research Area Cell Signaling & Signal Transduction, Other

References

There are 3 reference entries for this reagent.

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References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


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References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


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Inventor Information

Inventors

Pavel Sacha

Pavel Sacha

Jan Konvalinka

Jan Konvalinka

Jiří Schimer

Jiří Schimer

Tomas Knedlik

Tomas Knedlik

Jan Tykvart

Jan Tykvart

Frantisek Sedlak

Frantisek Sedlak

Pavel Majer

Pavel Majer

Vaclav Navratil

Vaclav Navratil

Petr Cigler

Petr Cigler

Vladimir Subr

Vladimir Subr

Karel Ulbich

Karel Ulbich

Jiri Stroham

Jiri Stroham

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