| Catalogue Number | 157998 |
| Synonyms | Fibroblast Activation Protein; prolyl endopeptidase FAP |
| Relevance |
Targeting human Fibroblast Activation Protein (FAP) using FAP specific inhibitor. - iBodies® are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation. - These iBodies® consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores). - These iBodies® have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays. |
| Key Attributes |
HPMA conjugate characteristics: MW: 79 875g/mol #Biotins/molecule: 8 Fluorochrome name: ATTO488 #Fluorochrome/molecule: 5 iBodies(R) is a registered trade mark of IOCB Tech s.r.o. |
| Research Area | Cell Signaling & Signal Transduction, Other |
Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.
Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.
Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.
Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.
Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.
Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.
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Pavel Sacha |
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Jan Konvalinka |
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Jiří Schimer |
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Tomas Knedlik |
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Jan Tykvart |
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Frantisek Sedlak |
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Pavel Majer |
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Vaclav Navratil |
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Petr Cigler |
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Vladimir Subr |
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Karel Ulbich |
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Jiri Stroham |
