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Negative control iBody (ATTO488)

Invented by Jiri Strohalm, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Karel Ulbich, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Petr Cigler, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Pavel Majer, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Frantisek Sedlak, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Tomas Knedlik, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Jiri Schimer, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Jan Konvalink, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Pavel Sacha, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Sub Vladlmir, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Jan Tykvart, at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry Vaclav Navratil at Institute of Organic Chemistry and Biochemistry, Charles University, Institute of Macromolecular Chemistry

Info

Catalogue Number 157770
Relevance - iBodies® are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation.
- These iBodies® consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores).
- These iBodies® have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays.
Research Area Cancer, Cell Signaling & Signal Transduction, Other
Storage Storage at -20°C; solubility H2O; stable at RT, 4°C and -80°C
Notes HPMA conjugate characteristics:
MW: 78 041 g/mol
#Biotins/molecule: 8
Fluorochrome name: ATTO488
#Fluorochrome/molecule: 5

References

There are 3 reference entries for this reagent.

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References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


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References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


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Inventor Information

Inventors

Jiri Strohalm

Jiri Strohalm

Karel Ulbich

Karel Ulbich

Petr Cigler

Petr Cigler

Pavel Majer

Pavel Majer

Frantisek Sedlak

Frantisek Sedlak

Tomas Knedlik

Tomas Knedlik

Jiri Schimer

Jiri Schimer

Jan Konvalink

Jan Konvalink

Pavel Sacha

Pavel Sacha

Sub Vladlmir

Sub Vladlmir

Jan Tykvart

Jan Tykvart

Vaclav Navratil

Vaclav Navratil

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