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anti-GST tag iBody small molecule (tool compound)

Invented by Jan Konvalinka , Jiří Schimer , Tomas Knedlik , Vaclav Navratil , Jan Tykvart , Frantisek Sedlak , Pavel Majer , Petr Cigler , Jiri Strohalm , Karel Ulbich , Vladimir Subr , Sacha Pavel
Invented at Institute of Organic Chemistry and Biochemistry , Institute of Macromolecular Chemistry , Charles University

Info

Catalogue Number 157997
Antigen/Gene or Protein Targets Tageting Glutathione S-Transferase (GST) tagged proteins using GST-specific inhibitor
Synonyms Ligandins; GST; GST-tag
Relevance GST (Glutathione S-Transferase) is a 26kDa protein encoded by the parasitic helminth Schistosoma japonicum and widely used in the pGEX family of GST plasmid expression vectors as a fusion protein with foreign proteins.

- iBodies® are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation.
- These iBodies® consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores).
- These iBodies® have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays.
Research Area Cell Signaling & Signal Transduction, Other
Notes iBodies(R) is a registered trade mark of IOCB Tech s.r.o.

References

There are 3 reference entries for this reagent.

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References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


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References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


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Inventor Information

Inventors

Jan  Konvalinka

Jan Konvalinka

Jiří  Schimer

Jiří Schimer

Tomas Knedlik

Tomas Knedlik

Vaclav Navratil

Vaclav Navratil

Jan  Tykvart

Jan Tykvart

Frantisek Sedlak

Frantisek Sedlak

Pavel Majer

Pavel Majer

Petr Cigler

Petr Cigler

Jiri Strohalm

Jiri Strohalm

Karel Ulbich

Karel Ulbich

Vladimir Subr

Vladimir Subr

Sacha  Pavel

Sacha Pavel

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