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anti-glutamate carboxypeptidase (GCPII) iBody small molecule (tool compound)
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Invented by Jan Konvalinka , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Jiří Schimer , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Tomas Knedlik, at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Jan Tykvart , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Frantisek Sedlak , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Pavel Majer , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Vaclav Navratil , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Petr Cigler , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Vladimir Subr , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Karel Ulbich , at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Jiri Stroham, at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University Pavel Sacha at Institute of Organic Chemistry and Biochemistry, Institute of Macromolecular Chemistry, Charles University

Info

Catalogue Number 157994
Antigen/Gene or Protein Targets Targeting human Glutamate Carboxypeptidase II (GPCII) using GPCII specific inhibitor
Synonyms Glutamate Carboxypeptidase II, N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, prostate-specific membrane antigen (PSMA)
Relevance An enzyme that in humans is encoded by FOLH1 (folate hydrolase 1).

- iBodies® are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation.
- These iBodies® consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores).
- These iBodies® have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays.
Research Area Cell Signaling & Signal Transduction, Other
Notes HPMA conjugate characteristics:
MW: 148 800g/mol
#Biotins/molecule: 38
Fluorochrome name: ATTO488
#Fluorochrome/molecule: 7

iBodies(R) is a registered trade mark of IOCB Tech s.r.o.

References

There are 3 reference entries for this reagent.

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References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


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References: 3 entries

Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.

Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.

Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.


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Inventor Information

Inventors

Jan Konvalinka

Jan Konvalinka

Jiří  Schimer

Jiří Schimer

Tomas Knedlik

Tomas Knedlik

Jan Tykvart

Jan Tykvart

Frantisek Sedlak

Frantisek Sedlak

Pavel Majer

Pavel Majer

Vaclav Navratil

Vaclav Navratil

Petr Cigler

Petr Cigler

Vladimir Subr

Vladimir Subr

Karel Ulbich

Karel Ulbich

Jiri Stroham

Jiri Stroham

Pavel Sacha

Pavel Sacha

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