#157993

anti-carbonic anhydrase IX (CA-IX) iBody small molecule (tool compound)

Cat. #157993

anti-carbonic anhydrase IX (CA-IX) iBody small molecule (tool compound)

Cat. #: 157993

Sub-type: Marker

Availability: Please enquire for quantities and pricing

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Jan Konvalinka ; Jirí Schimer ; Tomas Knedlik ; Jan Tykvart ; Frantisek Sedlak ; Pavel Majer ; Vaclav Navratil ; Petr Cigler ; Vladimir Subr ; Karel Ulbich ; Jiri Stroham ; Pavel Sacha

Institute: Institute of Organic Chemistry and Biochemistry ; Institute of Macromolecular Chemistry ; Charles University

Tool Details
Handling
Target Details
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: anti-carbonic anhydrase IX (CA-IX) iBody small molecule (tool compound)
  • Alternate name: Carbonic Anyhdrase IX; CA9; CA-IX
  • Tool sub type: Marker
  • Primary target: Targeting human Carbonic Anhydrase (CAIX) using CAIX specific inhibitor
  • Description: An enzyme that in humans is encoded by the CA9 gene. - iBodiesŽ are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation. - These iBodiesŽ consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging prob...
  • Purpose: Marker
  • Additional notes: HPMA conjugate characteristics: MW: 111 000g/mol #Biotins/molecule: 33 Fluorochrome name: ATTO488 #Fluorochrome/molecule: 6 iBodies(R) is a registered trade mark of IOCB Tech s.r.o.

Handling

  • Shipping conditions: Dry Ice

Target Details

  • Primary target: Targeting human Carbonic Anhydrase (CAIX) using CAIX specific inhibitor

Related Tools

  • Related tools: anti-fibroblast activation protein (FAP) iBody small molecule (tool compound) ; anti-GST tag iBody small molecule (tool compound) ; anti-his tag iBody small molecule (tool compound) ; anti- HIV-1 protease iBody small molecule (tool compound) ; anti-glutamate carboxypeptidase (GCPII) iBody small molecule (tool compound) ; Negative control iBody (ATTO488) ; anti-neuraminidase iBody small molecule (tool compound)

References

  • Ĺ imon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.
  • DvořákovĂĄ et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.
  • Ĺ ĂĄcha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.