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Fungi Endoplasmic Reticulum Tracker 5 small molecule (tool compound)
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Invented by Micha Fridman; Benhamou Raphael; Herzog Ido M; Jaber Qais Z at Tel Aviv University

Info

Antigen/Gene or Protein Targets Endoplasmic Reticulum
Type Fluorescent Probe
Relevance In fungal cells, the endoplasmic reticulum (ER) harbours several of the enzymes involved in the biosynthesis of ergosterol, an essential membrane component, making this organelle the site of action of antifungal azole drugs, used as a first-line treatment for fungal infections. This marker provides specific fluorescent labelling of this organelle in cells of live pathogenic fungi. Specifically, the marker is an antifungal azole-based fluorescent tracking reagent of the ER in live fungal cells.The fungal ER tracker is a unique molecular tool useful in the study of the ER and its interactions with other organelles in live cells of pathogenic fungi.

PMID: 30427174
Selectivity Highly specific for Endoplasmic Reticulum.
Molecular Formula C25H25BF4N6O2Na
Key Attributes Optimised to fungi
Tracks ER in live fungal cells
Demonstrates specificity
Evaluated in relevant pathogens
Superior to other commercial ER trackers

PMID: 30427174
Molecular Weight (g/mol) 550.2014
In vitro applications Tracking of the ER in live fungal cells (e.g. Candida).
Solubility DMSO
Research Area Cell Type or Organelle Marker, Cell Structure and Motility, Fluorescent Cell Imaging
Storage -15ºC to -25ºC, light protection
Notes This tracker is optimised for use in fungi, not mammalian or plant cells and has shown superiority to other commercially available ER trackers. It has been evaluated in a panel of Candida, including C. albicans and C. glabrata which are considered the two most common fungal pathogens relevant to human infection. There is weak background signal and high specificity.

PMID: 30427174

References

There are 1 reference entries for this reagent.

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References: 1 entry

Benhamou et al. 2018. ACS Chem Biol. 13(12):3325-3332. PMID: 30427174.


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References: 1 entry

Benhamou et al. 2018. ACS Chem Biol. 13(12):3325-3332. PMID: 30427174.


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Inventor Information

Inventors

Micha Fridman; Benhamou Raphael; Herzog Ido M; Jaber Qais Z

Micha Fridman; Benhamou Raphael; Herzog Ido M; Jaber Qais Z

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