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Selective CB2R photoaffinity probe (LEI-121) small molecule (tool compound)

Info

Catalogue Number 156467
Antigen/Gene or Protein Targets Type 2 cannabinoid receptor (CB2R) - a G protein-coupled receptor (GPCR)
Type Fluorescent Probe
Relevance Photoreactive probe to study the type 2 cannabinoid receptor (CB2R). LEI121 is the first CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. An incorproated alkyne serves as ligation handle for the introduction of reporter groups.
Molecular Formula C31H29F4N6O4S [M+H]+
Key Attributes CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. LEI121 enables target engagement studies and visualization of endogenously expressed CB2R.
Molecular Weight (g/mol) 657
In vitro applications Enables target engagement studies and visualisation of endogenously expressed CB2R.
Research Area Drug Discovery & Development, Fluorescent Cell Imaging, Structural Biology
Notes Using proteomics, LEI-121 has shown to identify multidrug resistance protein 1, protein disulfide-isomerase, glutathione S-transferase Mu 6, 26S proteasome non-ATPase regulatory subunit 3 O and mitochondrial carnitine.acylcarnitine carrier protein.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Soethoudt et al. 2018. Cannabis Cannabinoid Res. 3(1):136-151. PMID: 29992186.

Soethoudt et al. 2018. J Am Chem Soc. 140(19):6067-6075. PMID: 29420021.


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References: 2 entries

Soethoudt et al. 2018. Cannabis Cannabinoid Res. 3(1):136-151. PMID: 29992186.

Soethoudt et al. 2018. J Am Chem Soc. 140(19):6067-6075. PMID: 29420021.


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