Selective CB2R photoaffinity probe (LEI-121) small molecule (tool compound)
Invented at Leiden University and Leiden University Medical Center
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 156467 |
| Antigen/Gene or Protein Targets | Type 2 cannabinoid receptor (CB2R) - a G protein-coupled receptor (GPCR) |
| Type | Fluorescent Probe |
| Relevance | Photoreactive probe to study the type 2 cannabinoid receptor (CB2R). LEI121 is the first CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. An incorproated alkyne serves as ligation handle for the introduction of reporter groups. |
| Molecular Formula | C31H29F4N6O4S [M+H]+ |
| Key Attributes | CB2R-selective bifunctional probe that covalently captures CB2R upon photoactivation. LEI121 enables target engagement studies and visualization of endogenously expressed CB2R. |
| Molecular Weight (g/mol) | 657 |
| In vitro applications | Enables target engagement studies and visualisation of endogenously expressed CB2R. |
| Research Area | Drug Discovery & Development, Fluorescent Cell Imaging, Structural Biology |
| Notes | Using proteomics, LEI-121 has shown to identify multidrug resistance protein 1, protein disulfide-isomerase, glutathione S-transferase Mu 6, 26S proteasome non-ATPase regulatory subunit 3 O and mitochondrial carnitine.acylcarnitine carrier protein. |
References: 2 entries
Soethoudt et al. 2018. Cannabis Cannabinoid Res. 3(1):136-151. PMID: 29992186.
Soethoudt et al. 2018. J Am Chem Soc. 140(19):6067-6075. PMID: 29420021.
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References: 2 entries
Soethoudt et al. 2018. Cannabis Cannabinoid Res. 3(1):136-151. PMID: 29992186.
Soethoudt et al. 2018. J Am Chem Soc. 140(19):6067-6075. PMID: 29420021.
Add a reference
