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Monoclonal Antibodies

HtrA3 Monoclonal Antibody (Clone 6G6)

Invented at Hudson Institute Of Medical Research
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Info

Catalogue Number 154232
Applications IHC WB
Antigen/Gene or Protein Targets Long isoform Human HtrA3 (high temperature requirement factor A)
Synonyms HtrA3, High-temperature requirement factor A3,
Pregnancy-related serine protease
Reactivity Human
Relevance Potential marker for preeclampsia. Detection of endogenous HtrA3 proteins in human serum HtrA3 are oligomeric serine proteases involved in protein quality control , regulate signal transduction in cell growth, apoptosis, inflammation in cancer, arthritis, neurodegenerative and neuromuscuclar disorders, age-related macular degeneration, pregnancy-specific disease preecampsia
Host Mouse
Immunogen HtrA3-L-S305A protein
Immunogen UniProt ID P83110, HTRA3_HUMAN
Molecular Weight (kDa) 48 kDa (46.9 kDa plus 1 kDa for the His tag)
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions Sp2/0 myeloma cells in the presence of 50% (w/v) polyethylene glycol 1500. Cells resuspendedin Hybridoma Serum Free Medium (Invitrogen), supplemented with 10% (w/v) FCS, HAT medium (Invitrogen) and IL-6 (1:1000 dilution).
Strain Balb/c
Notes Human studies of long-isoform of HtrA3 only
Research Area Gynaecaology, Reproductive Biology

References

There are 6 reference entries for this reagent.

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References: 6 entries

Wang et al. 2018. SLAS Discov. 23(10):1092-1099. PMID: 27932697.

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HtrA3 Isoform-Specific ELISAs for Early Detection of Preeclampsia.

Europe PMC ID: 27932697

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Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.

Europe PMC ID: 25248123

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Singh et al. 2014. PLoS One. 9(9):e108235. PMID: 25248123.

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HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening.

Europe PMC ID: 23049902

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Dynon et al. 2012. PLoS One. 7(9):e45956. PMID: 23049902.

View  

Add a reference

References: 6 entries

Wang et al. 2018. SLAS Discov. 23(10):1092-1099. PMID: 27932697.

View  

HtrA3 Isoform-Specific ELISAs for Early Detection of Preeclampsia.

View  

Activity-modulating monoclonal antibodies to the human serine protease HtrA3 provide novel insights into regulating HtrA proteolytic activities.

View  

Singh et al. 2014. PLoS One. 9(9):e108235. PMID: 25248123.

View  

HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening.

View  

Dynon et al. 2012. PLoS One. 7(9):e45956. PMID: 23049902.

View  

Add a reference

Inventor Information

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Invented at

Hudson Institute Of Medical Research
Hudson Institute Of Medical Research

16 reagents listed on Ximbio