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Anti-p53 [Pab 246]

Invented by David Lane at Karolinska Institutet

Info

Catalogue Number 151412
Applications IHC IP
Antigen/Gene or Protein Targets p53 mouse, wild type only
Reactivity Mouse
Relevance Mutant p53 is the commonest genetic change so far identified in a number of major carcinomas.
Host Mouse
Immunogen SV40-transformed cell line Balb/c SVA31 E7.
Subclass IgG1
Molecular Weight (kDa) 50
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 10% FCS or RPMI 1640 + 5% FCS
Strain Balb/c
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 10 entries

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.

Europe PMC ID: 19018287

Labalette et al. 2008. PLoS One. 3(11):e3761. PMID: 19018287.

Han et al. 2008. Cell Stem Cell. 2(3):241-51. PMID: 18371449.

SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization.

Europe PMC ID: 18371449

Gannon et al. 1990. EMBO J. 9(5):1595-602. PMID: 1691710.

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

Europe PMC ID: 1691710

Yewdell et al. 1986. J Virol. 59(2):444-52. PMID: 2426467.

Monoclonal antibody analysis of p53 expression in normal and transformed cells.

Europe PMC ID: 2426467

Wade-Evans et al. 1985. EMBO J. 4(3):699-706. PMID: 2408882.

Precise epitope mapping of the murine transformation-associated protein, p53.

Europe PMC ID: 2408882


Add a reference

References: 10 entries

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.

Europe PMC ID: 19018287

Labalette et al. 2008. PLoS One. 3(11):e3761. PMID: 19018287.

Han et al. 2008. Cell Stem Cell. 2(3):241-51. PMID: 18371449.

SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization.

Europe PMC ID: 18371449

Gannon et al. 1990. EMBO J. 9(5):1595-602. PMID: 1691710.

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

Europe PMC ID: 1691710

Yewdell et al. 1986. J Virol. 59(2):444-52. PMID: 2426467.

Monoclonal antibody analysis of p53 expression in normal and transformed cells.

Europe PMC ID: 2426467

Wade-Evans et al. 1985. EMBO J. 4(3):699-706. PMID: 2408882.

Precise epitope mapping of the murine transformation-associated protein, p53.

Europe PMC ID: 2408882


Add a reference

References: 10 entries

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.

Labalette et al. 2008. PLoS One. 3(11):e3761. PMID: 19018287.

Han et al. 2008. Cell Stem Cell. 2(3):241-51. PMID: 18371449.

SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization.

Gannon et al. 1990. EMBO J. 9(5):1595-602. PMID: 1691710.

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

Yewdell et al. 1986. J Virol. 59(2):444-52. PMID: 2426467.

Monoclonal antibody analysis of p53 expression in normal and transformed cells.

Wade-Evans et al. 1985. EMBO J. 4(3):699-706. PMID: 2408882.

Precise epitope mapping of the murine transformation-associated protein, p53.


Add a reference


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