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PEO1 Cell Line
RECENTLY UPDATED

Invented by Simon Langdon at The University of Edinburgh

Info

Catalogue Number 151672
Host Human
Tissue Ovary
Disease Keywords Adenocarcinoma
Model Tumour line
Relevance The PEO1 Cell Line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. PEO1 is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma. The patient previously received cisplatin, 5-fluorouracil and chlorambucil treatment. PEO1 is tumourigenic in immunologically-deprived CBA mice. PEO1 exhibits good growth in semi-solid medium (agar). PEO1 is from the same patient as the PEO4 and PEO6 cell lines
Research Area
RECENTLY UPDATED
Cancer, Drug Discovery & Development
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum. Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 104 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C. Doubling time approximately 37 hours.
Cellosaurus ID CVCL_2686

References: 26 entries
RECENTLY UPDATED

Cruz et al. 2017. Cancer Genomics Proteomics. 14(1):35-51. PMID: 28031236.

FACS

Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins.

Europe PMC ID: 28031236

Coscia et al. 2016. Nat Commun. 7:12645. PMID: 27561551.

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.

Europe PMC ID: 27561551

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.

Europe PMC ID: 27206315

A comprehensive survey of the mutagenic impact of common cancer cytotoxics.

Europe PMC ID: 27161042

Szikriszt et al. 2016. Genome Biol. 17(1):99. PMID: 27161042.

Huang et al. 2015. Oncotarget. :. PMID: 26683361.

The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer.

Europe PMC ID: 26683361

Nevedomskaya et al. 2015. J Proteome Res. :. PMID: 26629888.

A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity.

Europe PMC ID: 26629888

Patel et al. 2015. Cell Oncol (Dordr). :. PMID: 26266765.

Metformin and epithelial ovarian cancer therapeutics.

Europe PMC ID: 26266765

Hearn et al. 2015. Proc Natl Acad Sci U S A. :. PMID: 26162681.

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.

Europe PMC ID: 26162681

Ren et al. 2015. J Steroid Biochem Mol Biol. 150:54-63. PMID: 25817828.

Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy.

Europe PMC ID: 25817828

Huntoon et al. 2013. Cancer Res. 73(12):3683-91. PMID: 23548269.

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.

Europe PMC ID: 23548269

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.

Europe PMC ID: 2386737

Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines.

Europe PMC ID: 3167862

Characterization and properties of nine human ovarian adenocarcinoma cell lines.

Europe PMC ID: 3167863


Add a reference

References: 26 entries
RECENTLY UPDATED

Cruz et al. 2017. Cancer Genomics Proteomics. 14(1):35-51. PMID: 28031236.

FACS

Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins.

Europe PMC ID: 28031236

Coscia et al. 2016. Nat Commun. 7:12645. PMID: 27561551.

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.

Europe PMC ID: 27561551

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.

Europe PMC ID: 27206315

A comprehensive survey of the mutagenic impact of common cancer cytotoxics.

Europe PMC ID: 27161042

Szikriszt et al. 2016. Genome Biol. 17(1):99. PMID: 27161042.

Huang et al. 2015. Oncotarget. :. PMID: 26683361.

The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer.

Europe PMC ID: 26683361

Nevedomskaya et al. 2015. J Proteome Res. :. PMID: 26629888.

A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity.

Europe PMC ID: 26629888

Patel et al. 2015. Cell Oncol (Dordr). :. PMID: 26266765.

Metformin and epithelial ovarian cancer therapeutics.

Europe PMC ID: 26266765

Hearn et al. 2015. Proc Natl Acad Sci U S A. :. PMID: 26162681.

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.

Europe PMC ID: 26162681

Ren et al. 2015. J Steroid Biochem Mol Biol. 150:54-63. PMID: 25817828.

Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy.

Europe PMC ID: 25817828

Huntoon et al. 2013. Cancer Res. 73(12):3683-91. PMID: 23548269.

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.

Europe PMC ID: 23548269

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.

Europe PMC ID: 2386737

Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines.

Europe PMC ID: 3167862

Characterization and properties of nine human ovarian adenocarcinoma cell lines.

Europe PMC ID: 3167863


Add a reference

References: 26 entries
RECENTLY UPDATED

Cruz et al. 2017. Cancer Genomics Proteomics. 14(1):35-51. PMID: 28031236.

FACS

Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins.

Coscia et al. 2016. Nat Commun. 7:12645. PMID: 27561551.

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.

A comprehensive survey of the mutagenic impact of common cancer cytotoxics.

Szikriszt et al. 2016. Genome Biol. 17(1):99. PMID: 27161042.

Huang et al. 2015. Oncotarget. :. PMID: 26683361.

The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer.

Nevedomskaya et al. 2015. J Proteome Res. :. PMID: 26629888.

A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity.

Patel et al. 2015. Cell Oncol (Dordr). :. PMID: 26266765.

Metformin and epithelial ovarian cancer therapeutics.

Hearn et al. 2015. Proc Natl Acad Sci U S A. :. PMID: 26162681.

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.

Ren et al. 2015. J Steroid Biochem Mol Biol. 150:54-63. PMID: 25817828.

Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy.

Huntoon et al. 2013. Cancer Res. 73(12):3683-91. PMID: 23548269.

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.

Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines.

Characterization and properties of nine human ovarian adenocarcinoma cell lines.


Add a reference


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