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PEA1 Cell Line

Invented by Simon Langdon at The University of Edinburgh

Info

Catalogue Number 151678
Host Human
Tissue Ovary
Disease Keywords Adenocarcinoma
Model Tumour line
Relevance The PEA1 cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. PEA1 is an adherent cell line derived from a malignant effusion from the pleural cavity of a patient with a poorly differentiated adenocarcinoma. PEA1 was collected prior to treatment with cisplatin and prednimustine. PEA1 exhibits poor growth in semi-solid medium (agar). PEA1 is from the same patient as the PEA2 cell line.
Research Area Cancer, Drug Discovery & Development
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 104 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C. Doubling time approximately 37 hours. RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum
Cellosaurus ID CVCL_2682

References: 4 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.


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References: 4 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.


Add a reference

References: 4 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.


Add a reference


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