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Anti-CD70 [TAN 1-7]

Info

Catalogue Number 151721
Applications ELISA FACS IF Fn
Antigen/Gene or Protein Targets CD70
Synonyms CD70 Molecule; Tumor Necrosis Factor Ligand Superfamily Member 7; CD27 Ligand; CD27LG; TNFSF7; CD27L; Tumor Necrosis Factor Ligand 8A; Surface Antigen CD70; Ki-24 Antigen; CD70 Antigen; TNLG8A
Reactivity Mouse
Relevance CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.
Host Rat
Immunogen Recombinant mouse CD70 (extracellular domain, aa residues 41-195)
Subclass IgG2a
Positive Control Activated dendritic cells
Myeloma Used NS0
Recommended Growing Conditions RPMI + 10%FCS+ Penicillin-Streptomycin
Notes This antibody is a non-depleting mAb that blocks the CD70-CD27 interaction.

Suggested Dilutions: 1-10mg/ml
Research Area Apoptosis and Programmed Cell Death, Cancer, Immunology, Stem Cell Biology

References: 3 entries

Arora et al. 2014. Immunity. 40(1):105-16. PMID: 24412610.

Fn

Taraban et al. 2008. J Immunol. 180(7):4615-20. PMID: 18354184.

Rowley et al. 2004. J Immunol. 172(10):6039-46. PMID: 15128787.


Add a reference

References: 3 entries

Arora et al. 2014. Immunity. 40(1):105-16. PMID: 24412610.

Fn

Taraban et al. 2008. J Immunol. 180(7):4615-20. PMID: 18354184.

Rowley et al. 2004. J Immunol. 172(10):6039-46. PMID: 15128787.


Add a reference

References: 3 entries

Arora et al. 2014. Immunity. 40(1):105-16. PMID: 24412610.

Fn

Taraban et al. 2008. J Immunol. 180(7):4615-20. PMID: 18354184.

Rowley et al. 2004. J Immunol. 172(10):6039-46. PMID: 15128787.


Add a reference


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