Anti-Keratin 7 & 8 [LDS65]
Invented by Prof Jenny Southgate from University Of York
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 151742 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | Keratin 7 and Keratin 8 |
| Reactivity | Human |
| Relevance |
Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. LdS 65 is useful for studies of epithelial cells and tumour origin. |
| Host | Mouse |
| Immunogen | Cytoskeletons of the human urothelial RT4 cell line |
| Subclass | Not Known |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Research Area | Cell Signaling & Signal Transduction |
References: 4 entries
Southgate et al. 1987. Lab Invest. 56(2):211-23. PMID: 2433501.
Primary culture of human oral epithelial cells. Growth requirements and expression of differentiated characteristics.
Europe PMC ID: 2433501
Trejdosiewicz et al. 1986. Exp Cell Res. 164(2):388-98. PMID: 2423348.
Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line.
Europe PMC ID: 2423348
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References: 4 entries
Southgate et al. 1987. Lab Invest. 56(2):211-23. PMID: 2433501.
Primary culture of human oral epithelial cells. Growth requirements and expression of differentiated characteristics.
Trejdosiewicz et al. 1986. Exp Cell Res. 164(2):388-98. PMID: 2423348.
Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line.
Add a reference
