Anti-HLA-DOB [DOB 10E6/5]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Info
| Catalogue Number | 151729 |
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | HLA-DOB |
| Reactivity | Human |
| Relevance | Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA DM. |
| Host | Mouse |
| Immunogen | C-terminal peptide MHC class II |
| Subclass | IgG1 kappa |
| Myeloma Used | Sp2/0-Ag14 |
| Strain | Balb/c |
| Research Area | Immunology |
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