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PEA2 Cell Line

Invented by Simon Langdon at The University of Edinburgh

Info

Catalogue Number 151679
Host Human
Tissue Ovary
Disease Keywords Adenocarcinoma
Model Tumour line
Relevance The PEA2 cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. PEA2 is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated adenocarcinoma. PEA2 was collected on relapse after treatment with cisplatin and prednimustine. PEA2 exhibits poor growth in semi-solid medium (agar). PEA2 is from the same patient as the PEA1 cell line
Research Area Cancer, Drug Discovery & Development
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 104 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C. Doubling time approximately 66 hours. RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum.
Cellosaurus ID CVCL_2683

References: 8 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.

Europe PMC ID: 27206315

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

Europe PMC ID: 25230021

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.

Europe PMC ID: 2386737

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Characterization and properties of nine human ovarian adenocarcinoma cell lines.

Europe PMC ID: 3167863


Add a reference

References: 8 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.

Europe PMC ID: 27206315

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

Europe PMC ID: 25230021

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.

Europe PMC ID: 2386737

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Characterization and properties of nine human ovarian adenocarcinoma cell lines.

Europe PMC ID: 3167863


Add a reference

References: 8 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.

Beaufort et al. 2014. PLoS One. 9(9):e103988. PMID: 25230021.

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Oestrogen receptor expression and the effects of oestrogen and tamoxifen on the growth of human ovarian carcinoma cell lines.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.

Characterization and properties of nine human ovarian adenocarcinoma cell lines.


Add a reference


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