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PEO4 Cell Line

Invented by Simon Langdon at The University of Edinburgh

Info

Catalogue Number 151673
Host Human
Tissue Ovary
Disease Keywords Adenocarcinoma
Model Tumour line
Relevance The PEO4 cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists. PEO4 is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma. The patient previously received cisplatin, 5-fluorouracil and chlorambucil treatment. PEO4 was collected after clinical resistance developed to chemotherapy. PEO4 is tumourigenic in immunologically-deprived CBA mice. PEO4 exhibits good growth in semi-solid medium (agar). PEO4 is from the same patient as the PEO1 and PEO6 cell lines
Research Area Cancer, Drug Discovery & Development
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum. Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 104 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C. Doubling time approximately 37 hours.
Cellosaurus ID CVCL_2690

References: 9 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Huang et al. 2015. Oncotarget. :. PMID: 26683361.

Shields et al. 2015. Mol Syst Biol. 11(12):842. PMID: 26655797.

Patel et al. 2015. Cell Oncol (Dordr). :. PMID: 26266765.

Hearn et al. 2015. Proc Natl Acad Sci U S A. :. PMID: 26162681.

Tuthill et al. 2015. Oncogene. 34(16):2138-44. PMID: 24909167.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.


Add a reference

References: 9 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Huang et al. 2015. Oncotarget. :. PMID: 26683361.

Shields et al. 2015. Mol Syst Biol. 11(12):842. PMID: 26655797.

Patel et al. 2015. Cell Oncol (Dordr). :. PMID: 26266765.

Hearn et al. 2015. Proc Natl Acad Sci U S A. :. PMID: 26162681.

Tuthill et al. 2015. Oncogene. 34(16):2138-44. PMID: 24909167.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.


Add a reference

References: 9 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Huang et al. 2015. Oncotarget. :. PMID: 26683361.

Shields et al. 2015. Mol Syst Biol. 11(12):842. PMID: 26655797.

Patel et al. 2015. Cell Oncol (Dordr). :. PMID: 26266765.

Hearn et al. 2015. Proc Natl Acad Sci U S A. :. PMID: 26162681.

Tuthill et al. 2015. Oncogene. 34(16):2138-44. PMID: 24909167.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Langdon et al. 1988. Cancer Res. 48(21):6161-5. PMID: 3167862.

Langdon et al. 1988. Cancer Res. 48(21):6166-72. PMID: 3167863.


Add a reference


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