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PEO6 Cell Line

Invented by Simon Langdon at The University of Edinburgh

Info

Catalogue Number 151674
Host Human
Tissue Ovary
Disease Keywords Adenocarcinoma
Model Tumour line
Relevance The PEO6 cell line is an adherent cell line derived from a malignant effusion from the peritoneal ascites of a patient with a poorly differentiated serous adenocarcinoma. The patient previously received cisplatin, 5-fluorouracil and chlorambucil treatment. PEO6 was collected at advanced, terminal stage disease. PEO6 is tumourigenic in immunologically-deprived CBA mice. PEO6 exhibits good growth in semi-solid medium (agar). PEO6 is from the same patient as the PEO1 and PEO4 cell lines This cell line is one of nine from the PE ovarian adenocarcinoma panel (derived from 4 patients at varying stages of ovarian cancer, isolated from various malignant sites, and at various treatment stages) which provides a model system for research into the mechanism of oestrogen action on ovarian adenocarcinoma tumour cells, and for the study of efficacy and toxicity of oestrogen protagonists.
Research Area Cancer, Drug Discovery & Development
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions Split sub-confluent cultures (70-80%) 1:4 to 1:10 seeding at 2- 3 x 104 cells/cm2 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C. Doubling time approximately 77 hours. RPMI-1640 + 2mM Glutamine + 2mM Sodium Pyruvate + 10% Foetal Bovine Serum.
Cellosaurus ID CVCL_2691

References: 3 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Degos et al. 1979. Gastroenterol Clin Biol. 3(10):735-9. PMID: 316786.


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References: 3 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Degos et al. 1979. Gastroenterol Clin Biol. 3(10):735-9. PMID: 316786.


Add a reference

References: 3 entries

Matassa et al. 2016. Cell Death Differ. :. PMID: 27206315.

Langdon et al. 1990. Br J Cancer. 62(2):213-6. PMID: 2386737.

Degos et al. 1979. Gastroenterol Clin Biol. 3(10):735-9. PMID: 316786.


Add a reference


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