Anti-Proliferation marker [JC1]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151401 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | Proliferation marker |
| Reactivity | Human |
| Relevance | JC1 detects a nuclear antigen, distinct from Ki67, present in proliferating cells. It is useful as a marker of proliferation in cases such as squamous cell carcinoma where the Ki67 index cannot be determined. |
| Host | Mouse |
| Immunogen | Pokeweed-stimulated lymphocytes |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 212 and 123 |
| Myeloma Used | P3/NS1/1-Ag4.1 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Notes | Ultroser G can be used at 1% if the cells are not growing well. |
| Research Area | Cancer, Cell Cycle, Cell Type or Organelle Marker, Neurobiology |
References: 8 entries
Li et al. 2017. J Exp Clin Cancer Res. 36(1):58. PMID: 28427443.
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.
Europe PMC ID: 28427443
Wang et al. 2016. Am J Cancer Res. 6(6):1331-44. PMID: 27429847.
EMMPRIN, SP1 and microRNA-27a mediate physcion 8-O-β-glucopyranoside-induced apoptosis in osteosarcoma cells.
Europe PMC ID: 27429847
Zhang et al. 2016. J Med Chem. 59(7):3562-8. PMID: 27006991.
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.
Europe PMC ID: 27006991
Garrido et al. 1992. J Clin Pathol. 45(10):860-5. PMID: 1430255.
Monoclonal antibody JC1: new reagent for studying cell proliferation.
Europe PMC ID: 1430255
Add a reference
References: 8 entries
Li et al. 2017. J Exp Clin Cancer Res. 36(1):58. PMID: 28427443.
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.
Wang et al. 2016. Am J Cancer Res. 6(6):1331-44. PMID: 27429847.
EMMPRIN, SP1 and microRNA-27a mediate physcion 8-O-β-glucopyranoside-induced apoptosis in osteosarcoma cells.
Zhang et al. 2016. J Med Chem. 59(7):3562-8. PMID: 27006991.
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.
Garrido et al. 1992. J Clin Pathol. 45(10):860-5. PMID: 1430255.
Monoclonal antibody JC1: new reagent for studying cell proliferation.
Add a reference
