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Trex1 R114H Mouse

Info

Catalogue Number 154030
Antigen/Gene or Protein Targets TREX1
Disease Keywords Lupus
Model Mutant
Relevance TREX1 encodes a DNA exonuclease and mutations in this gene result in multiple autoimmune disorders, including lupus. This particular mouse model mimics Aicardi-Goutières Syndrome, a form of Lupus.
Conditional No
Mouse Genetic Background/Cross History Mutant mice were generated on a 129S6/SvEvTac background using an allelic replacement strategy.
Research Area Immunology, Neurobiology, Cell Signaling & Signal Transduction, Drug Discovery & Development

References

There are 2 reference entries for this reagent.

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References: 2 entries

Grieves et al. 2015. Proc Natl Acad Sci U S A. 112(16):5117-22. PMID: 25848017.

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.

Europe PMC ID: 25848017


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References: 2 entries

Grieves et al. 2015. Proc Natl Acad Sci U S A. 112(16):5117-22. PMID: 25848017.

Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.


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