Anti-IREB2 [IREB2-46-18-1]
Invented by Dr Bruno Galy from Deutsches Krebsforschungszentrum (DKFZ) German Cancer Research Center
Invented at Deutsches Krebsforschungszentrum (DKFZ) German Cancer Research Center
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Info
![Testing of Anti-IREB2 [IREB2-46-18‐1] culture supernatants in western blotting.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/ea795068-576f-4bc3-b878-ece0bae51da5.png)
![Testing of Anti-IREB2 [IREB2-46-18‐1] culture supernatants in western blotting.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/ea795068-576f-4bc3-b878-ece0bae51da5.png)
![Image thumbnail for Anti-IREB2 [IREB2-46-18-1]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/ea795068-576f-4bc3-b878-ece0bae51da5.png)
| Catalogue Number | 153778 |
| Applications | ELISA IP WB |
| Antigen/Gene or Protein Targets | IREB2, Uniprot ID:Q811J3 |
| Synonyms | Iron regulatory protein 2 (IREB2) |
| Reactivity | Mouse |
| Relevance |
Monoclonal antibody which binds IREB2, involved in iron homeostasis. Background and Research Application IREB2 (iron regulatory protein 2) is an RNA binding protein and a central regulator of cellular iron homeostasis. This protein regulates iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. In humans IREB2 polymorphism is linked to chronic obstructive pulmonary disease (CPOD), lung cancer and Alzheimer's disease. IREB2-null mice suffer from anaemia, abnormal body iron distribution, and neurodegeneration. IREB2 also plays various roles in cancer. |
| Host | Rat |
| Immunogen | Full length His-tagged IREB2 of mouse origin, produced in E. coli |
| Immunogen UniProt ID | Q811J3 |
| Subclass | IgG2a |
| Myeloma Used | Sp2/0-Ag14 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Cell Structure and Motility, Metabolism, Neurobiology |
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