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Anti-ARNTL2, Polyclonal [ARNTL2]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets ARNTL2
Reactivity Human and Mouse
Relevance ARNTL2­CLOCK heterodimers activate E­box element (3'­CACGTG­5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E­box sites. This transactivation is inhibited by PER2 and CRY1. Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN). Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala.
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 70.9, 69.2, 66.5, 65.6, 65.5, 64.1 & 61.8 
Research Area Cardiovascular, Epigenetics & Nuclear Signalling, Neurobiology

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