Anti-TFE3, Polyclonal [TFE3]
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Info
| Applications | ELISA IF WB |
| Antigen/Gene or Protein Targets | TFE3 |
| Reactivity | Human and Mouse |
| Relevance | Transcription factor that specifically recognizes and binds E-box sequences (5'- CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. |
| Host | Rabbit |
| Immunogen | 3 synthetic peptides (human) conjugated to KLH |
| Formulation | 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal. |
| Method of Purification | Immunogen affinity purification |
| Molecular Weight (kDa) | 61.5 |
| Research Area | Epigenetics & Nuclear Signalling, Immunology |
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