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Anti-LMX1A, Polyclonal [LMX1A]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets LMX1A
Reactivity Human and Mouse
Relevance Acts as a transcriptional activator by binding to an A/T­rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. :Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta­cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T­rich sequence in the insulin promoter and
stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]).
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 42.747 (Isoform1)
14.615 (Isoform LMX1A­4AB)
Research Area Epigenetics & Nuclear Signalling, Neurobiology, Stem Cell Biology

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