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Anti-Pfs 48/45 [3E12]

Info

Applications N/A
Antigen/Gene or Protein Targets Pfs 48/45
Reactivity Plasmodium
Relevance Fertilization and zygote development are obligate features of the malaria parasite life cycle and occur during parasite transmission to mosquitoes. The surface protein PFS48/45 is expressed by male and female gametes of Plasmodium falciparum and PFS48/45 antibodies prevent zygote development and transmission. Pfs 48/45 is therefore a good target antigen of malaria transmission blocking antibodies.
Host Mouse
Immunogen Gametocytes of the 7G8 isolate of P. falciparum.
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Strain Balb/c
Notes Recognises the P. falciparum Pfs 48/45 antigen expressed on gametocytes of P. falciparum. Inhibitory in mosquito membrane feeding assays.
UK Biosafety level: 1
Research Area Parasitology

References: 1 entry

Carter et al. 1990. Parasite Immunol. 12(6):587-603. PMID: 1707506.


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References: 1 entry

Carter et al. 1990. Parasite Immunol. 12(6):587-603. PMID: 1707506.


Add a reference

References: 1 entry

Carter et al. 1990. Parasite Immunol. 12(6):587-603. PMID: 1707506.


Add a reference


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