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|Antigen/Gene or Protein Targets||Pfs 48/45|
|Relevance||Fertilization and zygote development are obligate features of the malaria parasite life cycle and occur during parasite transmission to mosquitoes. The surface protein PFS48/45 is expressed by male and female gametes of Plasmodium falciparum and PFS48/45 antibodies prevent zygote development and transmission. Pfs 48/45 is therefore a good target antigen of malaria transmission blocking antibodies.|
|Immunogen||Gametocytes of the 7G8 isolate of P. falciparum.|
Recognises the P. falciparum Pfs 48/45 antigen expressed on gametocytes of P. falciparum. Inhibitory in mosquito membrane feeding assays.
UK Biosafety level: 1
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