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Anti-MSP1 Block 3 [9.5]

Info

Applications N/A
Antigen/Gene or Protein Targets MSP-1 Block 3
Reactivity Plasmodium
Relevance In considering methods for immunological control of Plasmodium falciparum malaria it is essential to know more about antigenic diversity within and between natural populations of the parasite from major endemic areas. A successful malaria vaccine would stimulate an individual's immune system to respond to the malaria parasite and prevent serious clinical disease. Many different groups are currently developing potential vaccines. Several candidates are based on a protein called MSP1 (merozoite surface protein 1) which is found on the surface of the blood stage form of the malaria parasite.
Host Mouse
Immunogen Schizont extracts
Subclass IgG2b kappa
Notes Recognises the Block 3 region of MSP-1, specifically dependent on the presence of (127-Q) to (Q-287) version of Block 3. This sequence found in the MAD20/RO33 isolates (see Miller et al 1993 for details of MSP-1 sequence comparisons- MSP-1 residue numbering in this paper is slightly different.
UK Biosafety level: 1
Research Area Parasitology

References

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References: 1 entry

Dobaño et al. 2007. Infect Immun. 75(2):643-52. PMID: 17118989.


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References: 1 entry

Dobaño et al. 2007. Infect Immun. 75(2):643-52. PMID: 17118989.


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