Anti-Integrin alpha 3 [F35 177-1]
Invented by Prof Joyce Taylor-Papadimitriou from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 151096 |
| Applications | IHC IF |
| Antigen/Gene or Protein Targets | Integrin a3 (CD49c) |
| Reactivity | Human |
| Relevance | Integrins are heterodimeric cell surface receptors composed of a and b subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a3 is found on most cell types. Integrin a3 associates with b1 integrin to form integrin a3b1, which is one of the most abundant keratinocyte integrins and binds laminin 5. |
| Host | Mouse |
| Immunogen | MTSV1-7 HYE - human breast epithelial cells. |
| Subclass | IgG1 kappa |
| Myeloma Used | P3X63Ag8.653 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Research Area | Adhesion, Cancer |
References: 3 entries
Lustosa et al. 2014. ScientificWorldJournal. 2014:102541. PMID: 24737953.
McInroy et al. 2011. Exp Cell Res. 317(17):2468-78. PMID: 21821021.
Gaggioli et al. 2007. Nat Cell Biol. 9(12):1392-400. PMID: 18037882.
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References: 3 entries
Lustosa et al. 2014. ScientificWorldJournal. 2014:102541. PMID: 24737953.
McInroy et al. 2011. Exp Cell Res. 317(17):2468-78. PMID: 21821021.
Gaggioli et al. 2007. Nat Cell Biol. 9(12):1392-400. PMID: 18037882.
Add a reference
