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Anti-PLAP [HD 8B6]


Catalogue Number 151107
Applications ELISA IHC IF RIA
Antigen/Gene or Protein Targets Placental Alkaline Phosphatase (PLAP), Regan and Nagao isoenzymes.
Reactivity Human
Relevance Alkaline phosphatases are phosphodiesterases. The placental-specific isozyme of Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal human mature placenta, seminomas of testis and ovarian carcinomas. The detection of alkaline phosphatase in serum is a marker for ovarian and testicular cancer. HD 8B6 has potential uses in the diagnosis of ovarian and testicular tumours. The antibody detects both Regan and Nagao isoenzymes.
Host Mouse
Immunogen Fresh Hep-2 cells followed by booster injections of fresh Hep-2 cells that have had their surface expression of PLAP boosted in culture.
Subclass IgG2a
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Research Area Cancer, Cell Type or Organelle Marker

References: 4 entries

Sharp et al. 2010. PLoS One. 5(10):e13130. PMID: 20976190.


Wojtowicz et al. 2007. Cell. 130(6):1134-45. PMID: 17889655.


Durbin et al. 1988. Int J Cancer Suppl. 2:50-8. PMID: 2450848.


Durbin et al. 1988. Int J Cancer Suppl. 2:59-66. PMID: 3162446.


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