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Anti-PTPRC [HLe-1(2D1)]


Catalogue Number 151108
Applications FACS IHC IF
Antigen/Gene or Protein Targets Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45)
Reactivity Human
Relevance PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). Hle-1 can be used in a panel of several monoclonal antibodies to characterise tumours.
Host Mouse
Immunogen Human peripheral blood mononuclear cells.
Subclass IgG1
Molecular Weight (kDa) 180-220
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes The antibody clone name was called "Hle-1" in Cobbold et al., 1986. Proceedings of the 3rd International Workshop and Conference; Oxford, England. Oxford University Press; 1987. p. 788-803.
Research Area Cardiovascular, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Neurobiology, Stem Cell Biology

References: 3 entries

Lee et al. 2004. Int Immunol. 16(8):1109-24. PMID: 15210650.

Tchilian et al. 2001. J Immunol. 166(2):1308-13. PMID: 11145714.

Bradstock et al. 1980. J Natl Cancer Inst. 65(1):33-42. PMID: 6993744.

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