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Anti-Integrin a2 [HAS-4]


Catalogue Number 151105
Applications FACS IHC IF IP
Antigen/Gene or Protein Targets Integrin a2 (CD49b)
Synonyms Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin b1 (CD29) to form the heterodimer integrin a2b1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-4 co-precipitates integrin a2b1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen.
Host Mouse
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction, Metabolism

References: 4 entries

Malara et al. 2011. Blood. 117(8):2476-83. PMID: 21131589.

Owens et al. 2001. Cancer Res. 61(13):5248-54. PMID: 11431366.

Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.

Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.

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