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Anti-Integrin a2 [HAS-4]

Invented by Prof Fiona Watt at King's College London

Info

Catalogue Number 151105
Applications FACS IHC IF IP
Antigen/Gene or Protein Targets Integrin a2 (CD49b)
Synonyms Integrin Subunit Alpha 2; Alpha 2 Subunit Of VLA-2 Receptor; Platelet Membrane Glycoprotein Ia; CD49 Antigen-Like Family Member B; Collagen Receptor; CD49B; GPIa; Very Late Activation Protein 2 Receptor, Alpha-2 Subunit; Human Platelet Alloantigen System 5; Platelet Glycoprotein GPIa; Platelet Antigen Br; VLA-2 Subunit Alpha; CD49b Antigen; HPA-5; VLA-2; VLAA2; BR
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2 associates with integrin b1 (CD29) to form the heterodimer integrin a2b1, which is one of the most abundant keratinocyte integrins, is found distributed in the basal layer of epidermis and binds collagen. HAS-4 co-precipitates integrin a2b1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen.
Host Mouse
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction, Metabolism

References: 8 entries

Malara et al. 2011. Blood. 117(8):2476-83. PMID: 21131589.

Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A.

Europe PMC ID: 21131589

Owens et al. 2001. Cancer Res. 61(13):5248-54. PMID: 11431366.

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.

Europe PMC ID: 11431366

Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.

Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels.

Europe PMC ID: 9443900

Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes.

Europe PMC ID: 7521749


Add a reference

References: 8 entries

Malara et al. 2011. Blood. 117(8):2476-83. PMID: 21131589.

Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A.

Europe PMC ID: 21131589

Owens et al. 2001. Cancer Res. 61(13):5248-54. PMID: 11431366.

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.

Europe PMC ID: 11431366

Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.

Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels.

Europe PMC ID: 9443900

Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes.

Europe PMC ID: 7521749


Add a reference

References: 8 entries

Malara et al. 2011. Blood. 117(8):2476-83. PMID: 21131589.

Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A.

Owens et al. 2001. Cancer Res. 61(13):5248-54. PMID: 11431366.

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.

Alford et al. 1998. J Cell Sci. 111 ( Pt 4):521-32. PMID: 9443900.

Integrin-matrix interactions affect the form of the structures developing from human mammary epithelial cells in collagen or fibrin gels.

Tenchini et al. 1993. Cell Adhes Commun. 1(1):55-66. PMID: 7521749.

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes.


Add a reference


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