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Anti-Cytochrome P450 3A1 [P6]


Catalogue Number 151141
Applications ELISA FACS WB
Antigen/Gene or Protein Targets Cytochrome P450 3A1, CYP3A1
Reactivity Human, Mouse and Rat
Relevance The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
Host Mouse
Immunogen Rat liver cytochrome P450 3A1
Subclass IgG1
Recommended Growing Conditions DMEM + 5% FCS
Notes P6 is highly specific for members of the CYP 3A gene family and cross reacts with CY 3A4 in human, CYP 3A in rat and potentially CYP 3A11 (based on inducibility) in mice.
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

References: 3 entries

Probert et al. 2014. Toxicol Sci. 137(2):350-70. PMID: 24235770.


Hu et al. 2011. Drug Metab Dispos. 39(3):419-25. PMID: 21135265.

Matuskova et al. 2009. Neuro Endocrinol Lett. 30 Suppl 1:41-5. PMID: 20027143.

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