Anti-Cytochrome P450 3A1 [P6]
Invented by Prof Roland Wolf from University of Dundee
Invented at University of Dundee
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151141 |
| Applications | ELISA FACS WB |
| Antigen/Gene or Protein Targets | Cytochrome P450 3A1, CYP3A1 |
| Reactivity | Human, Mouse and Rat |
| Relevance | The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. |
| Host | Mouse |
| Immunogen | Rat liver cytochrome P450 3A1 |
| Subclass | IgG1 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Notes |
P6 is highly specific for members of the CYP 3A gene family and cross reacts with CY 3A4 in human, CYP 3A in rat and potentially CYP 3A11 (based on inducibility) in mice. This reagent was created through a research collaboration between Cancer Research UK and Syngenta Crop Protection AG. |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism |
References: 6 entries
Probert et al. 2014. Toxicol Sci. 137(2):350-70. PMID: 24235770.
WB
Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies.
Europe PMC ID: 24235770
Hu et al. 2011. Drug Metab Dispos. 39(3):419-25. PMID: 21135265.
Opposite effect of diabetes mellitus induced by streptozotocin on oral and intravenous pharmacokinetics of verapamil in rats.
Europe PMC ID: 21135265
Matuskova et al. 2009. Neuro Endocrinol Lett. 30 Suppl 1:41-5. PMID: 20027143.
Influence of probiotics on rat liver biotransformation enzymes.
Europe PMC ID: 20027143
Add a reference
References: 6 entries
Probert et al. 2014. Toxicol Sci. 137(2):350-70. PMID: 24235770.
WB
Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies.
Hu et al. 2011. Drug Metab Dispos. 39(3):419-25. PMID: 21135265.
Opposite effect of diabetes mellitus induced by streptozotocin on oral and intravenous pharmacokinetics of verapamil in rats.
Matuskova et al. 2009. Neuro Endocrinol Lett. 30 Suppl 1:41-5. PMID: 20027143.
Influence of probiotics on rat liver biotransformation enzymes.
Add a reference
Inventor Information
Inventors
|
Prof Roland Wolf |
