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Anti-MSP2 Block 4 [12.5]

Info

Applications N/A
Antigen/Gene or Protein Targets MSP-2 (type A)
Reactivity Plasmodium
Relevance In considering methods for immunological control of Plasmodium falciparum malaria it is essential to know more about antigenic diversity within and between natural populations of the parasite from major endemic areas. A successful malaria vaccine would stimulate an individual's immune system to respond to the malaria parasite and prevent serious clinical disease. Many different groups are currently developing potential vaccines. Several Plasmodium falciparum genes show extensive genetic polymorphism. This phenomenon is exploited for genetic finger printing and for assessing parasite population dynamics. For instance, high polymorphism has been shown in msp1, msp2 and glurp genes in different geographical locations in malaria endemic areas
Host Mouse
Immunogen Schizonts (T9 isolate as immunogen)
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Notes Recognises MSP-2 Block 4 in an allele-specific manner. Positive for isolate PB1 but negative for MAD20 and K1 isolates
UK Biosafety level: 1
Research Area Parasitology

References: 1 entry

McBride et al. 1984. Trans R Soc Trop Med Hyg. 78(1):32-4. PMID: 6200967.


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References: 1 entry

McBride et al. 1984. Trans R Soc Trop Med Hyg. 78(1):32-4. PMID: 6200967.


Add a reference

References: 1 entry

McBride et al. 1984. Trans R Soc Trop Med Hyg. 78(1):32-4. PMID: 6200967.


Add a reference


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