KARPAS 620 Cell Line
Invented by Abraham Karpas at University of Cambridge
- Datasheet
- References (2)
- Inventor Info
Info
| Antigen/Gene or Protein Targets | IgG-kappa plasma cell leukaemia (PCL) |
| Host | Human |
| Tissue | Blood |
| Disease Keywords | Cancer; haemotology; leukemia; multiple myeloma |
| Relevance |
The KARPAS 620 cell line is a Human Plasma Cell Leukemia cell line useful in oncology research. The line has the same hypotetraploid karyotype as the fresh cells from the patient. The cultured cells have the ultrastructural appearance of plasma cells with abundant rough endoplasmic reticulum (RER) and secrete kappa light chain. They are positive for surface antigens HLA DR, and WR17 (CD 37) and negative for CD1, CD3, CD4 and CD8. |
| Production Details | Human Plasma Cell Leukemia cell line useful in oncology research. Established from the peripheral blood of a 77-year-old woman at diagnosis of plasma cell leukemia (IgGkappa) in 1987; plasma cell leukemia is related to multiple myeloma. |
| Research Area | Cancer, Drug Discovery & Development |
| Growth/Phenotype Keywords | Single round to polymorph cells |
| Recommended Growing Conditions | Cells can be maintained in humidified incubator with 5% CO2 at 37 ⁰C.Culture medium: RPMI 1640 + 20% Fetal bovine serum (FBS) |
| Cellosaurus ID | CVCL_1823 |
References: 2 entries
Drexler et al. 2000. Leuk Res. 24(8):681-703. PMID: 10936422.
Nacheva et al. 1990. Br J Haematol. 74(1):70-6. PMID: 2310698.
Add a reference
References: 2 entries
Drexler et al. 2000. Leuk Res. 24(8):681-703. PMID: 10936422.
Nacheva et al. 1990. Br J Haematol. 74(1):70-6. PMID: 2310698.
Add a reference
Inventor Information
Inventors
|
Abraham Karpas |
