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KARPAS 620 Cell Line

Invented by Abraham Karpas

Info

Antigen/Gene or Protein Targets IgG-kappa plasma cell leukaemia (PCL)
Host Human
Tissue Blood
Disease Keywords Cancer; haemotology; leukemia; multiple myeloma
Relevance The KARPAS 620 cell line is a Human Plasma Cell Leukemia cell line useful in oncology research.
The line has the same hypotetraploid karyotype as the fresh cells from the patient. The cultured cells have the ultrastructural appearance of plasma cells with abundant rough endoplasmic reticulum (RER) and secrete kappa light chain. They are positive for surface antigens HLA DR, and WR17 (CD 37) and negative for CD1, CD3, CD4 and CD8.
Production Details Human Plasma Cell Leukemia cell line useful in oncology research. Established from the peripheral blood of a 77-year-old woman at diagnosis of plasma cell leukemia (IgGkappa) in 1987; plasma cell leukemia is related to multiple myeloma.
Research Area Cancer, Drug Discovery & Development
Growth/Phenotype Keywords Single round to polymorph cells
Recommended Growing Conditions Cells can be maintained in humidified incubator with 5% CO2 at 37 ⁰C.Culture medium: RPMI 1640 + 20% Fetal bovine serum (FBS)
Cellosaurus ID CVCL_1823

References

There are 2 reference entries for this reagent.

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References: 2 entries

Drexler et al. 2000. Leuk Res. 24(8):681-703. PMID: 10936422.

Nacheva et al. 1990. Br J Haematol. 74(1):70-6. PMID: 2310698.


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References: 2 entries

Drexler et al. 2000. Leuk Res. 24(8):681-703. PMID: 10936422.

Nacheva et al. 1990. Br J Haematol. 74(1):70-6. PMID: 2310698.


Add a reference

Inventor Information