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Applications
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IHC
IF
IP
WB
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Antigen/Gene or Protein Targets
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Herpes Simplex Virus VP21/VP22a (scaffold)
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Reactivity
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Virus
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Relevance
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Herpes simplex virus (HSV) virions are multilayered, and their assembly requires several steps (reviewed in references 21 and 59). The double-stranded DNA viral genome is enclosed within a well-ordered protein capsid. A more amorphous layer of proteins referred to as the tegument surrounds the capsid. Lying outside of the tegument, the outermost layer of the virion consists of a lipid envelope containing viral glycoproteins. Herpes simplex virus type 1 (HSV-1) capsids are initially assembled with an internal protein scaffold. The scaffold proteins, encoded by overlapping in-frame UL26 and UL26.5 transcripts, are essential for formation and efficient maturation of capsids.
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Host
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Mouse
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Immunogen
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Herpes Simplex Virus Type-1 VP21/VP22a scaffold protein
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Subclass
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IgG2a
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Notes
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Works well for immunofluorescence (IF) on fixed specimens and for immunoprecipitiation (IP) on triton solubilised samples. Can be used to detect protein by Western blot.
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Research Area
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Virology
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