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Notch-2 is a transmembrane receptor, which contains 5 ankyrin repeats, 29-36 EGF repeats, 3 Notch/Lin repeats. It is highly expressed in the brain, lung, and thymus (CD4-CD8- cells and CD4-CD8+ cells). Lower levels of expression are observed in spleen, bone marrow, spinal cord, eyes, mammary gland, liver, intestine, kidney and heart. Notch-2 regulates a broad spectrum of various cell lineage commitment process, including myogenesis, neurogenesis, gliogenesis and lymphocyte development. Mutation of Notch-2 can cause a rare genetic disorder, Alagille syndrome, with multiple defects in liver, heart and other systems.
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