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Anti-iASPP [49.3]

Info

Applications FACS IF IP
Antigen/Gene or Protein Targets iASPP
Reactivity Human
Relevance The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1). So far, the best-known function of the ASPP family members is their ability to regulate the apoptotic function of p53 and its family members, p63 and p73. Biochemical and genetic evidence has shown that ASPP1 and ASPP2 activate, whereas iASPP inhibits, the apoptotic but not the cell-cycle arrest function of p53.
Host Mouse
Immunogen C-terminal His-tagged fusion protein containing amino acids 459-639 of iASPP
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

References

There are 1 reference entries for this reagent.

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References: 1 entry

Slee et al. 2004. Oncogene. 23(56):9007-16. PMID: 15489900.


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References: 1 entry

Slee et al. 2004. Oncogene. 23(56):9007-16. PMID: 15489900.


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