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|Applications||ELISA IF IP WB|
|Antigen/Gene or Protein Targets||TAF12 (formerly TAFII20)|
|Relevance||Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.|
|Immunogen||Recombinant human TAF12 protein.|
Available in 100ul unit as ascites.
Epitope is localised at the C-terminal part of TAF12.
Recommended dilutions: 1/500 - 1/5000
|Research Area||Epigenetics & Nuclear Signalling|
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