Anti-TAF10 [6TA-2B11]
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| Applications | ELISA IHC IF WB |
| Antigen/Gene or Protein Targets | TAF10 |
| Reactivity | Human and Mouse |
| Relevance | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. |
| Host | Mouse |
| Immunogen | Human TAF10 (TAFII30) as a fusion protein |
| Subclass | IgG1 kappa |
| Notes |
Recognises the EGAISNGVYVLP epitope from aa. 89-100 Available in 100ul unit as ascites |
| Research Area | Epigenetics & Nuclear Signalling |
References: 6 entries
Metzger et al. 1999. EMBO J. 18(17):4823-34. PMID: 10469660.
Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes.
Europe PMC ID: 10469660
Wieczorek et al. 1998. Nature. 393(6681):187-91. PMID: 9603525.
Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II.
Europe PMC ID: 9603525
Jacq et al. 1994. Cell. 79(1):107-17. PMID: 7923369.
Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.
Europe PMC ID: 7923369
Add a reference
References: 6 entries
Metzger et al. 1999. EMBO J. 18(17):4823-34. PMID: 10469660.
Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes.
Europe PMC ID: 10469660
Wieczorek et al. 1998. Nature. 393(6681):187-91. PMID: 9603525.
Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II.
Europe PMC ID: 9603525
Jacq et al. 1994. Cell. 79(1):107-17. PMID: 7923369.
Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.
Europe PMC ID: 7923369
Add a reference
References: 6 entries
Metzger et al. 1999. EMBO J. 18(17):4823-34. PMID: 10469660.
Mammalian TAF(II)30 is required for cell cycle progression and specific cellular differentiation programmes.
Wieczorek et al. 1998. Nature. 393(6681):187-91. PMID: 9603525.
Function of TAF(II)-containing complex without TBP in transcription by RNA polymerase II.
Jacq et al. 1994. Cell. 79(1):107-17. PMID: 7923369.
Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.
Add a reference
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