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Anti-Keratin7,13,17 & 18 [LdS 23]


Catalogue Number 151114
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Keratin 7,13,17 & 18
Reactivity Human
Relevance Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. Keratin 17 is expressed in suprabasal keratinocytes of wounded epidermis. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. LdS 23 is useful for studies of epithelial cells and tumour origin.
Host Mouse
Immunogen Cytoskeletons of the human urothelial RT4 cell line
Subclass IgG1
Recommended Growing Conditions DMEM + 5% FCS
Research Area Cell Signaling & Signal Transduction

References: 1 entry

Trejdosiewicz et al. 1986. Exp Cell Res. 164(2):388-98. PMID: 2423348.

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