Anti-Keratin7,13,17 & 18 [LdS 23]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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- References (2)
- Inventor Info
Info
| Catalogue Number | 151114 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | Keratin 7,13,17 & 18 |
| Reactivity | Human |
| Relevance | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue- and differentiation-specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. Keratin 17 is expressed in suprabasal keratinocytes of wounded epidermis. Keratins 8 and 18 are two of the first keratins expressed in the embryo, and persist into adult tissues as the keratin pair representing minimal epithelial keratin expression. Keratins 8 and 18 are major components of all simple epithelia (but not of stratified squamous epithelia) and adenocarcinomas. LdS 23 is useful for studies of epithelial cells and tumour origin. |
| Host | Mouse |
| Immunogen | Cytoskeletons of the human urothelial RT4 cell line |
| Subclass | IgG1 kappa |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Research Area | Cell Signaling & Signal Transduction |
References: 2 entries
Trejdosiewicz et al. 1986. Exp Cell Res. 164(2):388-98. PMID: 2423348.
Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line.
Europe PMC ID: 2423348
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References: 2 entries
Trejdosiewicz et al. 1986. Exp Cell Res. 164(2):388-98. PMID: 2423348.
Phenotypic analysis of cultured melanoma cells. Expression of cytokeratin-type intermediate filaments by the M5 human melanoma cell line.
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