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Anti-POLR2A [1PB-7G5]

Info

Applications ChIP ELISA IF IP WB
Antigen/Gene or Protein Targets RNA Polymerase B subunit
Reactivity Human
Relevance RNA Polymerase B subunit (POLR2A) is the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Host Mouse
Immunogen TSPSYSPTSPSYSPTSPSYSP
Subclass IgG1 kappa
Notes Available in 100ul unit
Research Area Epigenetics & Nuclear Signalling

References: 4 entries

Helmlinger et al. 2006. PLoS Biol. 4(3):e67. PMID: 16494529.

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

Europe PMC ID: 16494529

Besse et al. 1995. Gene Expr. 4(3):143-61. PMID: 7734948.

Synthesis and maturation of viral transcripts in herpes simplex virus type 1 infected HeLa cells: the role of interchromatin granules.

Europe PMC ID: 7734948


Add a reference

References: 4 entries

Helmlinger et al. 2006. PLoS Biol. 4(3):e67. PMID: 16494529.

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

Europe PMC ID: 16494529

Besse et al. 1995. Gene Expr. 4(3):143-61. PMID: 7734948.

Synthesis and maturation of viral transcripts in herpes simplex virus type 1 infected HeLa cells: the role of interchromatin granules.

Europe PMC ID: 7734948


Add a reference

References: 4 entries

Helmlinger et al. 2006. PLoS Biol. 4(3):e67. PMID: 16494529.

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

Besse et al. 1995. Gene Expr. 4(3):143-61. PMID: 7734948.

Synthesis and maturation of viral transcripts in herpes simplex virus type 1 infected HeLa cells: the role of interchromatin granules.


Add a reference


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